Mephedrone (4-MMC) Synthesis [2B4M, Ethyl Acetate, Methylamine HCl]

[William D.]

As Hanna520 wrote in the another thread, it is better to prepare alc. methylamine for this synthesis. You will get fewer problems associated with the hydrolysis of ethyl acetate. You can use triethylamine, ethanol or methanol, or THF. Get a solution of gas and a precipitate of salts without water. It is easy to separate by decanting and you can start your synthesis more successfully. For small quantities this is usually not a problem, but if you want to synthesize several kg at a time it will be significantly different.

 

[Ranbir Singh]

Hellow sir can I boiling after layer saperate than acidification
Any problem

 

[Dr. MMX]

Yes this is very good reagent, to ensure maximum precise, but most important is 2b4m, rest matters less

 

[zetvasa9]

Hello, we have synthesized this method 3 times but we do not get more than 30% yield, what could be the problem? We follow the technology 1 in 1 as described in the guide

 

[handle]

I'm next going to try to extend reaction time by 1 hour from 4 hours up too over night. with light heating 28-33c after the forth hour, as thats when my reaction starts to cool down naturally.,

 

[SpaceRocket]

I did 2 batches yesterday. I let one batch react for 2 hours at 30 degrees Celsius. I let the other batch react for 45 minutes, but then at a high temperature. The maximum temperature was 54.5 degrees Celsius. With these batches, much more HCl was added at the end than with the 2 batches before. This is usually a sign that there will be more end product.

 

[handle]

we could try an alternate solvent like DMSO rather than Ethyl Acetate, maybe? IDK sorry.

 

[nimrod313]

WWork with dcm no more 38⁰

 

[handle]

I can never get it to 5.5 !! its always hangs around 7 - 8, then sometimes jumps straight up to 4...
So Annoying... by that time i think it has already mostly all come out of solution anyway, is there any point adding more HCl if solution has already precipitated? at 7 or 8?

 

[nimrod313]

Better make it 5-6 if you got salts dilute it for better stirr

 

[zetvasa9]

Hello, we have synthesized this method 3 times but we do not get more than 30% yield, what could be the problem? We follow the technology 1 in 1 as described in the guide. But the product comes out very good quality

 

[nimrod313]

Work with other solvent

 

[Alchemistfromthahood]

The last time I made 4 mmc, I used HCl gas instead of hydrochloric acid.
The result was better.
Perhaps it's the water, as some of the salt dissolves during precipitation. The experts among us can certainly provide better information on this.just wanted to try this way

 

[Russian lab assistant]

Hi, how did you use HCI gas? Can you tell me more?

 

[Alchemistfromthahood]

Hello
i used the instructions from this article

Dry HCl gas from muriatic and sulfuric acids conc.

Dripping an affordable muriatic acid (HCl aq 31%) over concentrated sulfuric acid (H2SO4) is one of the best methods for producing a dry gaseous HCl, if it is necessary to quickly scaling. The reaction rate and temperature is easily controlled. Capacities are easily and quickly cleaned, and if...

bbgate.com

the tubes should be teflon because other materials will dissolve
tube inside the freebase solution and you can start
it takes a while till you get the right settings for your setup but when you have it works great and safety

 

[Alchemistfromthahood]

Read this article and you have everything you have to know for this operation

 

[G.Patton]

Read more here https://safrole.com/knowledge-base/how-to-make-dry-hcl-gas/

 

[Alchemistfromthahood]

nice that you share it
thx