Question there seems to be a debate about the quality of the meth through nabh4

jade52

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i know that nabh4 method is the most preferred one due to its scalability,

but quality wise, some say nabh4 meth has weaker effect and effect time even after separation of the racemic into d - isomer

as far as i know, from p2p, there are al/hg, nabh4, leuckart

anyone tried each synth? which method had the best quality? regarding they all had same isomer separation/purification/recrystalizing process

(didnt even consider ephedrine/pesudoephedrine method due to its cost and limitation in big scale)
 
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