Synthesis of Mephedrone

[Himik]

Hello Dear Friends - I would like to contact the Experts. I have in stock for the synthesis of Mephedrone Bk4 Methylamine hydrochloride Dichloromethane Sodium hydroxide Hydrochloric acid 37% Acetone. Please tell me how to make a 38-40% solution of Methylamine in water using Methylamine hydrochloride for this - Thanks in advance

 

[loadingST]

Add 1M methylamine in apropriate water to be 40% afther removal of the chloride anion and add 1M NaOH slowly to the sollution.

 

[Himik]

Incorrect - I have already done this. All Methylamine Gas evaporates instantly because a lot of sodium chloride is formed in the water solution.

 

[Himik]

It is necessary to obtain methylamine gas in a closed vessel and saturate the water through a tube. This gas is 600 g of water + 400 g of methylamine gas.

 

[loadingST]

Sodium chloride not interact qith most aminations, and it works, gassing water gives cleaner solution of course but its not that easy as the procedure i writed.

 

[Himik]

So I have very poor quality Bk4 with 3 kg of Bk4 I got 800g of mephedrone

 

[Himik]

Perhaps the problem is in the poor quality of Bk4

 

[prvnc]

To make a 38-40% methylamine solution, dissolve methylamine HCl in water (1:1 molar ratio with NaOH). Add NaOH to freebase the methylamine, then distill or collect the gas into chilled water. Adjust concentration by dilution. Use proper ventilation and safety precautions. For exact ratios, check standard organic synthesis references. Stay safe!

 

[poo]

Can I have an expert opinion on this. Thank you

Pour 300ml of benzene into a 2-litre flask, then slowly add 100g of 2-bromo-4-methylpropiophenone while stirring at 350 RPM. Next, carefully introduce 140ml of a 40% aqueous methylamine solution at a rate of about one drop per second over a period of 30 minutes, without applying any external heat. The typical duration for the reaction to transition from self-heating to cooling down ranges from 2.5 to 3.5 hours. Once the temperature starts to drop, the reaction has concluded.