I'm investigating the glycidic ester synthesis route, and have some questions.
I've seen two pathways. One uses not solvent, but does use sodium methylate. It is water sensitive. The other uses DMF and a phase transfer catalyst.
My question is, can dmf be replaced with ethyl acetate?
In addition, can the phase transfer catalyst, TEBAC was used, be replaced with CTAC, or cetyltrimethylammpnium chloride? It is very accessible and not suspicious at all.
Furthermore, could the route with sodium methylate replace the methylate with hydroxide and a phase transfer catalyst, especially CTAC? Would greatly simplify things, even if yield was reduced.
I've seen two pathways. One uses not solvent, but does use sodium methylate. It is water sensitive. The other uses DMF and a phase transfer catalyst.
My question is, can dmf be replaced with ethyl acetate?
In addition, can the phase transfer catalyst, TEBAC was used, be replaced with CTAC, or cetyltrimethylammpnium chloride? It is very accessible and not suspicious at all.
Furthermore, could the route with sodium methylate replace the methylate with hydroxide and a phase transfer catalyst, especially CTAC? Would greatly simplify things, even if yield was reduced.